Guido Uguzzoni

Researcher at Gen&Chem team - BGE - IRIG - CEA-Grenoble.

IRIG CEA-Grenoble, bâtC3 · 17, rue des Martyrs

38054 Grenoble Cedex 9, France

CEA BGE UGA

My research focuses on developing AI methods for molecular biology, bioinformatics and protein design, with a focus on medical applications. I work at the intersection of machine learning, statistical physics, and computational biology, using deep sequencing data to train AI models that generate optimized biomolecules. My research combines fundamental work with practical applications. I collaborate with experimental groups to design specific systems such as peptides, antibodies, and viral capsids.

By applying AI to molecular biology, I am committed to creating data-driven solutions that accelerate the discovery and optimization of biomolecules for medical purposes.

news

selected publications

  1. Large-scale identification of coevolution signals across homo-oligomeric protein interfaces by direct coupling analysis
    Guido Uguzzoni, Shalini John Lovis, Francesco Oteri, and 3 more authors
    Proceedings of the National Academy of Sciences, 2017
  2. Efficient generative modeling of protein sequences using simple autoregressive models
    Jeanne Trinquier, Guido Uguzzoni, Andrea Pagnani, and 2 more authors
    Nature communications, 2021
  3. Inference and design of antibody specificity: from experiments to models and back
    Jorge Fernandez-de-Cossio-Diaz, Guido Uguzzoni, Kévin Ricard, and 4 more authors
    PLOS Computational Biology, 2024

collaborators

Christophe Batail — BGE - CEA
Jorge Ferndandez de Cossio Diaz — IPhT - CEA
Darren Hart — IBS - CEA
Clement Nizak — Sorbonne Université
Olivier RIvoire — ESPCI Paris
Deniz Dalkara — Institut de la Vision Paris
Ulisse Ferrari — Institut de la Vision Paris
Serena Marchiò — Università di Torino

alumni

PhD students
2025 - present The-Choung TRINH — AI models in pharmacogenomics
supervisor: C.Batail (CEA)
2025 - present Nicola De Simone — Biostatistics and machine learning in Proteomics
supervisor: T.Burger(CEA)
M2/M1 internships
2026 Hector Pezet — Ontology-guided AI GraphRAG framework in bioinformatics
Past members
2020 - 2023 Luca Sesta — Inference models of protein fitness landscapes
supervisor: A.Pagnagni (Politecnico di Torino)
now: PostDoc Biozentrum - University of Basel